Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326890 | 0.82 | MAPT (0.55) | ADORA2BALDH1A1ADORA2AKDM4EMAPT | |
| SCHEMBL9461663 | 0.76 | GAA (0.46) | ADORA2BALDH1A1ADORA2AKDM4EMAPT | |
| SCHEMBL9658453 | 0.73 | ESR1 (0.43) | ALDH1A1KDM4EMAPTADORA3SMN1; SMN2 | |
| SCHEMBL7325184 | 0.72 | HRH3 (0.53) | ADORA2BALDH1A1ADORA2AKDM4EMAPT | |
| SCHEMBL8265386 | 0.72 | MAPT (0.50) | ADORA2BALDH1A1ADORA2AMAPTHPGD | |
| SCHEMBL22257276 | 0.71 | KMT2A (0.58) | ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL10474306 | 0.71 | MAPT (0.65) | KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7338149 | 0.71 | LMNA (0.61) | ALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL11196264 | 0.71 | KDM4E (0.49) | ALDH1A1KDM4EPTPN1 | |
| Hydrochloric Acid SCHEMBL20529584 | 0.70 | KMT2A (0.56) | ALDH1A1KDM4EMAPTCYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |