SCHEMBL7327082

SCHEMBL7327082

CCNc1cc(=O)c2c(O)cccc2o1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 7/20 0.50
CYP3A4 P08684 4/20 0.50
MAPT P10636 4/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
ALOX15 P16050 2/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP1A1 P04798 1/20 0.50
CYP1A2 P05177 1/20 0.50
PKM P14618 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CYP1B1 Q16678 1/20 0.50
FTO Q9C0B1 1/20 0.50
HTR2B P41595 6/20 0.49
ATM Q13315 1/20 0.49
HTR3A P46098 1/20 0.49
MAPK1 P28482 2/20 0.49
RAF1 P04049 1/20 0.49
HPGD P15428 1/20 0.49
KDM4E B2RXH2 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL115397 0.76 HTR2B (0.64) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL31398697 0.76 RXRA (0.69) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL31398703 0.74 AR (0.55) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL24248100 0.74 POLH (0.56) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL31670262 0.74 MAPT (0.64) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL620145 0.74 MAPT (0.64) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL11745063 0.74 AHR (0.54) CYP3A4MAPTMEN1KMT2ACYP1A1
SCHEMBL7326715 0.73 ATM (0.52) ARCYP3A4MAPTMEN1KMT2A
SCHEMBL7319426 0.73 AKR1B1 (0.53) CYP3A4MEN1KMT2AALDH1A1CYP1A2
SCHEMBL17716251 0.71 POLH (0.56) ARCYP3A4MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5703075-A Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones PHARMACIA & UPJOHN COMPANY (US) 1997-12-30 US disclosed
EP-0525123-B1 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES UPJOHN CO (US) 1997-09-17 EP disclosed
EP-0525123-A1 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES. UPJOHN CO (US) 1993-02-03 EP disclosed
WO-1991019707-A2 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES THE UPJOHN COMPANY (US) 1991-12-26 WO disclosed
EP-0459983-A1 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES PHARMACIA & UPJOHN COMPANY (US) 1991-12-11 EP disclosed
WO-1990006921-A1 ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES THE UPJOHN COMPANY (US) 1990-06-28 WO disclosed