Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | PRKX | P51817 | 1/20 | 0.30 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326975 | 0.93 | CHRM1 (0.40) | CHRM1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL7327000 | 0.86 | CDK2 (0.31) | ROCK2PRKXPRKCEPRKCDROCK1 | |
| SCHEMBL7320736 | 0.82 | CHRM1 (0.36) | CHRM1ROCK2PRKXPRKCEPRKCD | |
| SCHEMBL7360629 | 0.78 | CHRM1 (0.38) | CHRM1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL7318875 | 0.72 | ROCK2 (0.47) | LMNACYP3A4MAPK1PMP22ROCK2 | |
| SCHEMBL7327666 | 0.71 | CHRM1 (0.46) | CHRM1LMNACYP3A4MAPK1PMP22 | |
| SCHEMBL10050727 | 0.70 | LMNA (0.46) | CHRM1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL6994641 | 0.70 | CDK2 (0.53) | CHRM1LMNACYP3A4MAPTAPEX1 | |
| SCHEMBL7326984 | 0.69 | CHRM1 (0.46) | CHRM1LMNACYP3A4MAPK1PMP22 | |
| SCHEMBL5007289 | 0.68 | CYP3A4 (0.51) | CHRM1LMNACYP3A4MAPTAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |