SCHEMBL7328641

SCHEMBL7328641

c1ccc(COc2cc3ccccc3cc2-c2ncc[nH]2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IKBKB O14920 4/20 0.49
HTT P42858 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
STAT3 P40763 1/20 0.49
CASP1 P29466 1/20 0.46
ADRA1A P35348 1/20 0.45
ALOX5 P09917 1/20 0.43
CYP3A4 P08684 1/20 0.43
MTOR P42345 1/20 0.42
ADK P55263 1/20 0.42
NISCH Q9Y2I1 1/20 0.42
CYP19A1 P11511 2/20 0.42
CYP11B1 P15538 2/20 0.42
CYP11B2 P19099 2/20 0.42
PDE5A O76074 1/20 0.42
PDE4A P27815 1/20 0.42
PDE4B Q07343 1/20 0.42
PDE4C Q08493 1/20 0.42
PDE4D Q08499 1/20 0.42
MRGPRX4 Q96LA9 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10922444 0.77 MAPT (0.50) ADRA1AALOX5CYP3A4NSD2ABL1
SCHEMBL8541063 0.74 LTA4H (0.53) ADRA1AMTORADKNISCHCYP11B1
SCHEMBL4329170 0.74 ADRA2A (0.50) HTTSMN1; SMN2STAT3CASP1ADRA1A
SCHEMBL772053 0.74 NISCH (0.61) SMN1; SMN2CYP3A4MTORADKNISCH
SCHEMBL5756185 0.72 TSHR (0.56) SMN1; SMN2CYP3A4MTORADKNISCH
SCHEMBL8538130 0.72 MAOB (0.43) ALOX5CYP3A4NSD2ABL1PPARG
SCHEMBL10822527 0.71 SMN1; SMN2 (0.51) IKBKBHTTSMN1; SMN2STAT3ALOX5
SCHEMBL28687044 0.71 ALOX5 (0.60) HTTSMN1; SMN2STAT3ADRA1AALOX5
SCHEMBL24088205 0.71 HTR1A (0.48) ADRA1AMTORADKNISCHPDE5A
SCHEMBL18587436 0.70 MRGPRX4 (0.50) CYP3A4MTORADKNISCHCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002096397-A1 BICYCLIC AROMATIC CHEMOKINE RECEPTOR LIGANDS CHEMOKINE THERAPEUTICS CORPORATION (CA) 2002-12-05 WO disclosed
US-5866545-A ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; GASTROINTESTINAL DISORDERS; UROGENITAL DISORDERS MERCK & CO., INC. (US) 1999-02-02 US disclosed
WO-1995005192-A1 SUBSTITUTED KETONE DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME MERCK & CO., INC. (US) 1995-02-23 WO disclosed