Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328875 | 0.68 | HTR4 (0.43) | — | |
| SCHEMBL7348377 | 0.66 | GAA (0.37) | OPRD1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL9196790 | 0.66 | CNR2 (0.42) | OPRD1KDM4E | |
| SCHEMBL3646002 | 0.64 | ALDH1A1 (0.37) | — | |
| SCHEMBL7333320 | 0.64 | SLC6A4 (0.34) | OPRD1KDM4EMEN1RECQLKMT2A | |
| Hydrochloric Acid SCHEMBL9198794 | 0.64 | SLC6A4 (0.36) | OPRD1KDM4EMEN1RECQLKMT2A | |
| SCHEMBL7357794 | 0.63 | CNR2 (0.35) | OPRD1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL11219120 | 0.62 | TRPA1 (0.38) | KDM4EMEN1RECQLKMT2A | |
| SCHEMBL7346880 | 0.62 | OXER1 (0.36) | OPRD1CACNA2D1CACNA1BCACNB1KMT2A | |
| SCHEMBL7328048 | 0.62 | PTGER1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664806-A1 | HETEROCYCLIC CONDENSED BENZOIC ACID DERIVATIVES AS 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-08-02 | — | — | EP | claimed |
| WO-1994008995-A1 | HETEROCYCLIC CONDENSED BENZOIC ACID DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | claimed |