Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.60 |
| ▸ | LTA4H | P09960 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | NPY1R | P25929 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222152 | 0.82 | ALDH1A1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1ADORA3 | |
| SCHEMBL7326393 | 0.81 | HRH3 (0.53) | HRH3LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5646504 | 0.81 | KMT2A (0.70) | HRH3LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7327514 | 0.80 | LTA4H (0.52) | HRH3LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7137220 | 0.79 | ALDH1A1 (0.72) | HRH3NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL8058902 | 0.78 | HRH3 (0.61) | HRH3LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5697159 | 0.76 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1ADORA3 | |
| SCHEMBL7398931 | 0.76 | HRH3 (0.89) | HRH3LTA4HNPC1RAB9AKDM4E | |
| SCHEMBL8637452 | 0.75 | HRH3 (1.00) | HRH3LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8640984 | 0.75 | HRH3 (0.89) | HRH3LTA4HNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0629190-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-21 | — | — | EP | disclosed |
| WO-1993015052-A1 | COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-05 | — | — | WO | disclosed |