Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.54 |
| ▸ | HTR1A | P08908 | 10/20 | 0.54 |
| ▸ | HTR1B | P28222 | 9/20 | 0.54 |
| ▸ | HTR2A | P28223 | 8/20 | 0.54 |
| ▸ | HTR2C | P28335 | 5/20 | 0.54 |
| ▸ | HTR7 | P34969 | 5/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.54 |
| ▸ | HTR6 | P50406 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | HTR5A | P47898 | 2/20 | 0.54 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.54 |
| ▸ | MPO | P05164 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334134 | 0.83 | HTR1D (0.70) | HTR1DHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL8118432 | 0.81 | HTR1D (0.70) | HTR1DHTR1BHTR2ATRPM8MPO | |
| SCHEMBL27461445 | 0.80 | CSNK2A1 (0.55) | HTR1DHTR1AHTR1BMPO | |
| SCHEMBL2847185 | 0.73 | HTR1D (0.70) | HTR1DHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL27320748 | 0.72 | HTR1D (0.52) | HTR1DHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL6938670 | 0.71 | HTR1A (0.72) | HTR1DHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL387663 | 0.70 | MPO (1.00) | HTR1DHTR1AHTR1BHTR2AHTR2C | |
| Serotonin SCHEMBL1495 | 0.70 | HTR2C (1.00) | HTR1DHTR1AHTR1BHTR2AHTR2C | |
| Serotonin SCHEMBL29349412 | 0.70 | HTR2C (1.00) | HTR1DHTR1AHTR1BHTR2AHTR2C | |
| SCHEMBL8396474 | 0.70 | HTR1D (0.66) | HTR1DHTR1AHTR1BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | claimed |
| CN-1092765-A | New tryptamine analogues and preparation method thereof and purposes | SMITHKLINE BEECHAM PLC (GB) | 1994-09-28 | — | — | CN | claimed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | claimed |
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| CN-1092765-A | New tryptamine analogues and preparation method thereof and purposes | SMITHKLINE BEECHAM PLC (GB) | 1994-09-28 | — | — | CN | disclosed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |