Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817798 | 0.89 | HSD11B1 (0.41) | HSD11B1LMNAMAPK1MAPTMEN1 | |
| SCHEMBL7334097 | 0.88 | HSD11B1 (0.49) | HSD11B1LMNAMAPK1MAPTKMT2A | |
| SCHEMBL7336087 | 0.86 | HSD11B1 (0.52) | HSD11B1MAPK1MAPTMEN1KMT2A | |
| SCHEMBL7337656 | 0.84 | LMNA (0.44) | HSD11B1LMNAMAPK1MAPTMEN1 | |
| SCHEMBL7341323 | 0.83 | HSD11B1 (0.49) | HSD11B1MAPTTP53ALDH1A1L3MBTL1 | |
| SCHEMBL7337167 | 0.83 | HCRTR2 (0.41) | HSD11B1LMNAMAPK1EDNRASMN1; SMN2 | |
| SCHEMBL7336277 | 0.83 | HSD11B1 (0.48) | HSD11B1MAPTEDNRATP53SMN1; SMN2 | |
| SCHEMBL7342790 | 0.82 | HSD11B1 (0.58) | HSD11B1MAPT | |
| SCHEMBL7342900 | 0.81 | ALDH1A1 (0.40) | HSD11B1LMNAMAPK1MAPTMEN1 | |
| SCHEMBL7340189 | 0.81 | EDNRB (0.40) | HSD11B1KMT2AEDNRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |