Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334097 | 0.88 | HSD11B1 (0.49) | HSD11B1POLBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7827530 | 0.87 | HSD11B1 (0.43) | HSD11B1POLBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7339659 | 0.86 | HSD11B1 (0.54) | HSD11B1POLBMAPTTP53SMN1; SMN2 | |
| SCHEMBL7337057 | 0.83 | POLB (0.44) | HSD11B1POLBALDH1A1L3MBTL1HTT | |
| SCHEMBL7342790 | 0.83 | HSD11B1 (0.58) | HSD11B1POLBMAPT | |
| SCHEMBL7341323 | 0.83 | HSD11B1 (0.49) | HSD11B1POLBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7334114 | 0.83 | HSD11B1 (0.46) | HSD11B1MAPTALDH1A1L3MBTL1TP53 | |
| SCHEMBL7342900 | 0.80 | ALDH1A1 (0.40) | HSD11B1POLBMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7343148 | 0.80 | HSD11B1 (0.44) | HSD11B1MAPTALDH1A1L3MBTL1TP53 | |
| SCHEMBL7335669 | 0.79 | HSD11B1 (0.54) | HSD11B1POLBMAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |