Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | STAT3 | P40763 | 2/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334908 | 0.81 | HDAC3 (0.52) | GRK2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL7329662 | 0.80 | ACP1 (0.54) | GRK2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL7327541 | 0.76 | ALDH1A1 (0.50) | HDAC1HDAC8HDAC6ALDH1A1KMT2A | |
| SCHEMBL9477024 | 0.67 | BCHE (0.61) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL27344779 | 0.67 | KMT2A (0.33) | MAPTALDH1A1KMT2ALMNAROCK2 | |
| SCHEMBL5453827 | 0.66 | BCHE (0.51) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL4518077 | 0.66 | PORCN (0.64) | GRK2HDAC1MAPTALDH1A1KMT2A | |
| SCHEMBL8547667 | 0.66 | MEN1 (0.58) | GRK2HDAC1MAPTALDH1A1KMT2A | |
| SCHEMBL403203 | 0.66 | RAB9A (0.56) | GRK2HDAC1BCHEMAPTALDH1A1 | |
| SCHEMBL9912422 | 0.65 | BCHE (0.63) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046710-C | New 4-aminopyridines, process for preparing the same and medicaments containing the same | LUOHE DIAGNOSTIC EQUIPMENT CO (DE) | 1999-11-24 | — | — | CN | disclosed |
| EP-0687253-B1 | 4-AMINOPYRIDINES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS CONTAINING THE SAME | BOEHRINGER MANNHEIM GMBH (DE) | 1998-12-16 | — | — | EP | disclosed |
| CN-1119858-A | Aminopyridines, process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1996-04-03 | — | — | CN | disclosed |
| EP-0687253-A1 | NEW 4-AMINOPYRIDINES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS CONTAINING THE SAME | Roche Diagnostics GmbH (DE) | 1995-12-20 | — | — | EP | disclosed |
| WO-1994020467-A1 | NEW 4-AMINOPYRIDINES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS CONTAINING THE SAME | BOEHRINGER MANNHEIM GMBH (DE) | 1994-09-15 | — | — | WO | disclosed |