Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770539 | 0.78 | ALOX12 (0.54) | PLA2G7TSHRALOX12LMNAPOLB | |
| SCHEMBL8062425 | 0.77 | GSK3A (0.63) | GSK3AGSK3BTSHRABL1LMNA | |
| SCHEMBL8764222 | 0.74 | MGLL (0.52) | GSK3AGSK3BPLA2G7TSHRALOX15 | |
| SCHEMBL3318940 | 0.73 | GSK3A (1.00) | GSK3AGSK3BTSHRGAAPOLB | |
| SCHEMBL9770647 | 0.71 | RAB9A (0.66) | LMNAGAARECQLKMT2AMAPT | |
| SCHEMBL20339321 | 0.70 | GSK3A (0.69) | GSK3AGSK3BTSHRGAAMEN1 | |
| SCHEMBL7330913 | 0.70 | GSK3A (0.59) | GSK3AGSK3BTSHRABL1LMNA | |
| SCHEMBL17160680 | 0.70 | TSHR (0.48) | GSK3AGSK3BTSHRABL1LMNA | |
| SCHEMBL17160677 | 0.69 | GSK3A (0.57) | GSK3AGSK3BTSHRABL1LMNA | |
| SCHEMBL8661738 | 0.69 | GSK3A (0.57) | GSK3AGSK3BTSHRABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |