Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.74 |
| ▸ | TNF | P01375 | 2/20 | 0.74 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.74 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.74 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.74 |
| ▸ | CSF1R | P07333 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14281041 | 0.89 | KMT2A (0.80) | KMT2ANOD1TNFNOD2SOS1 | |
| SCHEMBL7165480 | 0.88 | TNF (0.87) | KMT2ANOD1TNFNOD2SOS1 | |
| SCHEMBL7337702 | 0.85 | NOD1 (1.00) | KMT2ANOD1TNFNOD2SOS1 | |
| SCHEMBL10353547 | 0.83 | KMT2A (0.71) | KMT2ANOD1TNFNOD2SOS1 | |
| SCHEMBL7168102 | 0.83 | KMT2A (0.71) | KMT2ANOD1TNFNOD2SOS1 | |
| SCHEMBL939417 | 0.83 | TNF (0.79) | KMT2ANOD1TNFNOD2SOS1 | |
| SCHEMBL10353137 | 0.83 | KMT2A (0.71) | KMT2ANOD1TNFNOD2SOS1 | |
| Hydrochloric Acid SCHEMBL10353113 | 0.82 | KMT2A (0.70) | KMT2ANOD1TNFNOD2SOS1 | |
| SCHEMBL10353548 | 0.82 | KMT2A (0.71) | KMT2AHTTCYP1A2CYP2D6HDAC3 | |
| SCHEMBL9630558 | 0.81 | TNF (0.75) | KMT2ANOD1TNFNOD2SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200377505-A1 | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF | GFB (ABC), LLC | 2020-12-03 | — | — | US | disclosed |
| WO-2019028308-A1 | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2019-02-07 | — | — | WO | disclosed |
| US-20080027044-A1 | Prodrug antibiotic screens | NORTHEASTERN UNIVERSITY | 2008-01-31 | — | — | US | disclosed |
| US-20080027044-A1 | Prodrug antibiotic screens | NORTHEASTERN UNIVERSITY | 2008-01-31 | — | — | US | disclosed |
| US-20080027044-A1 | Prodrug antibiotic screens | NORTHEASTERN UNIVERSITY | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377505-A1 | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF | AZI2, ATP6V1B1, GLS | KMT2A 1233/4885NOD1 3826/4885TNF 3981/4885 |
| US-20080027044-A1 | Prodrug antibiotic screens | O60361, PGLS, GUSB | KMT2A 3307/4885NOD1 876/4885TNF 2187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.