SCHEMBL7338172

SCHEMBL7338172

CCn1ncc2c(Cl)c3ccc(C(=O)O)cc3nc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 2/20 0.46
KMT2A Q03164 4/20 0.44
MEN1 O00255 3/20 0.44
MAPT P10636 3/20 0.44
GAA P10253 1/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
RAB9A P51151 3/20 0.44
NPC1 O15118 2/20 0.44
KDM4E B2RXH2 2/20 0.43
RECQL P46063 1/20 0.43
THRB P10828 1/20 0.42
HPGD P15428 1/20 0.42
CSNK2A2 P19784 4/20 0.41
CSNK2B P67870 4/20 0.41
NR3C1 P04150 5/20 0.41
PGR P06401 1/20 0.40
PDE4B Q07343 1/20 0.40
ADORA3 P0DMS8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7428137 0.81 NR3C1 (0.46) KMT2AMEN1MAPTGAAHTT
SCHEMBL7332532 0.79 MAOA (0.50) KMT2AMEN1MAPTGAASMN1; SMN2
SCHEMBL7338680 0.78 PDE1A (0.44) KMT2AMEN1MAPTRXFP1KDM4E
SCHEMBL7330355 0.77 LMNA (0.41) KMT2AMEN1MAPTRAB9ANPC1
SCHEMBL7332575 0.75 NPC1 (0.48) KMT2AMEN1MAPTGAASMN1; SMN2
SCHEMBL7337999 0.75 PDE5A (0.47) PDE4BADORA3ADORA2AADORA1
SCHEMBL7328414 0.74 RXFP1 (0.50) MAPTHTTRXFP1KDM4ERECQL
SCHEMBL7332950 0.73 ADORA2A (0.38) NR3C1PGRPDE4BADORA3ADORA2A
SCHEMBL7328438 0.72 PIM1 (0.43) MAPTRECQLNR3C1PGRPDE4B
SCHEMBL7330632 0.72 PDE1A (0.44) KMT2AMEN1MAPTGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0813533-A4 SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF SANOFI WINTHROP INC (US) 2000-01-19 EP disclosed
US-5942520-A Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines CELL PATHWAYS, INC. (US) 1999-08-24 US disclosed
EP-0813533-A1 SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF SANOFI WINTHROP, INC. (US) 1997-12-29 EP disclosed
WO-1996028446-A1 SUBSTITUTED N-CYCLOALKYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4 AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF SANOFI WINTHROP, INC. (US) 1996-09-19 WO disclosed
US-5488055-A ADMINISTERING GMP HOSPHODIESTERASE INHIBITORS FOR TREATMENT OF CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS SANOFI WINTHROP INC. (US) 1996-01-30 US disclosed