Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38243330 | 0.81 | TRPV4 (0.73) | TRPV4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL750886 | 0.81 | TRPV4 (0.73) | TRPV4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL7332669 | 0.79 | L3MBTL1 (0.48) | TRPV4ALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL7699644 | 0.77 | ALDH1A1 (0.56) | TRPV4ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL5783293 | 0.74 | TRPV4 (0.49) | TRPV4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL2947794 | 0.74 | TRPV4 (1.00) | TRPV4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL29420268 | 0.74 | TRPV4 (1.00) | TRPV4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL196430 | 0.72 | TRPV4 (0.65) | TRPV4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL4572998 | 0.71 | SMN1; SMN2 (0.65) | TRPV4ALDH1A1HPGDKDM4EPOLB | |
| SCHEMBL24457848 | 0.71 | TRPV4 (0.62) | TRPV4ALDH1A1HPGDKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997046207-A2 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-11 | — | — | WO | disclosed |
| EP-0804464-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996018644-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1996-06-20 | — | — | WO | disclosed |