Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | VDR | P11473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27549293 | 0.82 | HDAC4 (0.54) | L3MBTL1TP53HDAC4HDAC2HDAC8 | |
| SCHEMBL29482636 | 0.81 | L3MBTL1 (0.64) | L3MBTL1TP53TRPV4KMT2AALDH1A1 | |
| SCHEMBL407215 | 0.81 | L3MBTL1 (0.64) | L3MBTL1TP53TRPV4KMT2AALDH1A1 | |
| SCHEMBL7342191 | 0.79 | TRPV4 (0.58) | L3MBTL1TP53TRPV4KMT2AALDH1A1 | |
| SCHEMBL196223 | 0.75 | CA12 (0.68) | L3MBTL1HDAC4HDAC2HDAC8KMT2A | |
| SCHEMBL29482639 | 0.74 | TRPV4 (0.68) | L3MBTL1TP53TRPV4ALDH1A1GAA | |
| SCHEMBL74997 | 0.74 | TRPV4 (0.68) | L3MBTL1TP53TRPV4ALDH1A1GAA | |
| SCHEMBL289253 | 0.71 | TRPV4 (0.49) | L3MBTL1TP53TRPV4KMT2AALDH1A1 | |
| SCHEMBL29651902 | 0.71 | TRPV4 (0.49) | L3MBTL1TP53TRPV4KMT2AALDH1A1 | |
| SCHEMBL28188560 | 0.71 | ALDH1A1 (0.48) | L3MBTL1TP53TRPV4ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997046207-A2 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-11 | — | — | WO | disclosed |
| EP-0804464-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996018644-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1996-06-20 | — | — | WO | disclosed |