Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 8/20 | 0.68 |
| ▸ | F2 | P00734 | 4/20 | 0.51 |
| ▸ | PLG | P00747 | 4/20 | 0.51 |
| ▸ | KLK1 | P06870 | 4/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.51 |
| ▸ | F12 | P00748 | 4/20 | 0.51 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | C1R | P00736 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | HPN | P05981 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | C1S | P09871 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339708 | 0.93 | PLAU (0.60) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL7348627 | 0.87 | PLAU (0.60) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL7347825 | 0.85 | PLAU (0.58) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL7347409 | 0.83 | PLAU (0.52) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL7341600 | 0.81 | FTO (0.54) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL7337750 | 0.80 | F12 (0.71) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL31499213 | 0.79 | F12 (0.61) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL7347056 | 0.79 | FTO (0.53) | PLAUF2PLGKLK1PRSS1 | |
| Methane SCHEMBL11282601 | 0.79 | F2 (0.58) | PLAUF2PLGKLK1PRSS1 | |
| SCHEMBL10934547 | 0.78 | F12 (0.53) | PLAUF2PLGKLK1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170020838-A1 | TREATMENT FOR RESPIRATORY DISEASE | MUCOKINETICA LIMITED (GB) | 2017-01-26 | — | — | US | disclosed |
| US-20100092402-A1 | TREATMENT OF RESPIRATORY DISEASE | MUCOKINETICA LTD. (GB) | 2010-04-15 | — | — | US | disclosed |
| EP-0048433-B1 | NOVEL AMIDINE COMPOUNDS, PROCESS FOR PRODUCING SAME AND ANTI-COMPLEMENT AGENT COMPRISING THEM | TORII & CO., LTD. (JP) | 1986-05-28 | — | — | EP | disclosed |
| US-4532255-A | Amidine compounds and anticomplement agent comprising same | TORII & CO., LTD. (JP) | 1985-07-30 | — | — | US | disclosed |
| US-4454338-A | 6-AMIDINO-2-NATHTHYL-4-GUANIDINOBENZOATE | TORII & CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |
| EP-0048433-A2 | Novel amidine compounds, process for producing same and anti-complement agent comprising them | TORII & CO., LTD. (JP) | 1982-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100092402-A1 | TREATMENT OF RESPIRATORY DISEASE | OAT, HRH2, PAM | PLAU 454/4885F2 198/4885PLG 608/4885 |
| US-20170020838-A1 | TREATMENT FOR RESPIRATORY DISEASE | NUDT1, CFTR, P2RY4 | PLAU 1762/4885F2 2007/4885PLG 2568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.