Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | F9 | P00740 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23766641 | 0.80 | PRMT5 (0.59) | PRMT5WDR77RAB9ANPC1HSD17B10 | |
| Mannitol SCHEMBL28834478 | 0.80 | PDE4A (0.44) | HSD17B10ALDH1A1MAPT | |
| Mannitol SCHEMBL27910852 | 0.80 | KDM4E (0.44) | RAB9ANPC1HSD17B10TAAR1GAA | |
| SCHEMBL7765629 | 0.79 | LMNA (0.56) | RAB9ANPC1SLC1A3SMN1; SMN2PLAU | |
| SCHEMBL28897234 | 0.79 | RAB9A (0.50) | PRMT5WDR77RAB9ANPC1HSD17B10 | |
| SCHEMBL23766625 | 0.78 | NPC1 (0.56) | PRMT5WDR77RAB9ANPC1HSD17B10 | |
| SCHEMBL7349098 | 0.77 | SLC1A3 (0.43) | PRMT5WDR77RAB9ANPC1HSD17B10 | |
| SCHEMBL6726577 | 0.76 | PDE4A (0.48) | HSD17B10ALDH1A1MAPT | |
| SCHEMBL1225548 | 0.76 | NPC1 (0.58) | PRMT5WDR77RAB9ANPC1HSD17B10 | |
| SCHEMBL7689672 | 0.76 | NPC1 (0.58) | PRMT5WDR77RAB9ANPC1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397779-A1 | RENIN INHIBITING PEPTIDES WITH POLAR END GROUPS | THE UPJOHN COMPANY (US) | 1990-11-22 | — | — | EP | disclosed |
| EP-0329295-A1 | Renin inhibiting peptides with polar end groups | THE UPJOHN COMPANY (US) | 1989-08-23 | — | — | EP | disclosed |
| WO-1989007109-A1 | RENIN INHIBITING PEPTIDES WITH POLAR END GROUPS | THE UPJOHN COMPANY (US) | 1989-08-10 | — | — | WO | disclosed |