Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342254 | 0.98 | ALDH1A1 (0.40) | MMP2MMP9LMNAALDH1A1TP53 | |
| SCHEMBL7342248 | 0.98 | ALDH1A1 (0.40) | MMP2MMP9LMNAALDH1A1TP53 | |
| SCHEMBL6464595 | 0.97 | ALDH1A1 (0.39) | MMP2MMP9LMNAALDH1A1TP53 | |
| SCHEMBL28294340 | 0.86 | KMT2A (0.40) | MMP2MMP9LMNAALDH1A1TP53 | |
| SCHEMBL7345167 | 0.86 | LMNA (0.37) | MMP2MMP9LMNAALDH1A1TP53 | |
| SCHEMBL6535237 | 0.84 | SMN1; SMN2 (0.41) | MMP2MMP9LMNAALDH1A1TP53 | |
| SCHEMBL29033834 | 0.83 | ALDH1A1 (0.40) | MMP2MMP9LMNAALDH1A1TP53 | |
| SCHEMBL757884 | 0.83 | TP53 (0.48) | MMP2MMP9LMNAALDH1A1TP53 | |
| SCHEMBL8429495 | 0.82 | LMNA (0.39) | MMP2MMP9LMNAALDH1A1TP53 | |
| SCHEMBL8429588 | 0.82 | LMNA (0.39) | MMP2MMP9LMNAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4559325-A | ANTITUMOR AGENTS | BURZYNSKI STANISLAW R (US) | 1985-12-17 | — | — | US | disclosed |
| US-4558057-A | URINE EXTRACTS | BURZYNSKI STANISLAW R (US) | 1985-12-10 | — | — | US | disclosed |
| US-4470970-A | ANTITUMOR AND-CARCINOGENIC AGENT EXTRACTED FROM URINE | BURZYNSKI STANISLAW R | 1984-09-11 | — | — | US | disclosed |
| EP-0069232-A2 | Pharmaceutical composition comprising phenyl acetyl glutamine,a combination of this compound with phenylacetic acid or 3-(phenylacetylamino)piperidine-2,6-dione,a process for isolating the latter from urine and a process for the synthesis of 3-(phenylacetylamino)piperidine-2,6-dione | BURZYNSKI, Stanislaw R. (US) | 1983-01-12 | — | — | EP | disclosed |