Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | YAP1 | P46937 | 2/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345627 | 1.00 | PTPN1 (0.49) | PTPN1EPHX2MDM2SIRT2HDAC8 | |
| SCHEMBL2367217 | 0.85 | MDM2 (0.56) | PTPN1EPHX2MDM2 | |
| SCHEMBL7342692 | 0.84 | PTPN1 (0.57) | PTPN1YAP1BCL2 | |
| SCHEMBL7342697 | 0.84 | PTPN1 (0.57) | PTPN1YAP1BCL2 | |
| SCHEMBL7337146 | 0.84 | PTPN1 (0.51) | PTPN1MDM2YAP1BCL2 | |
| SCHEMBL7342635 | 0.84 | GPR132 (0.49) | PTPN1YAP1BCL2MAPTTDP1 | |
| SCHEMBL7342642 | 0.84 | GPR132 (0.49) | PTPN1YAP1BCL2MAPTTDP1 | |
| SCHEMBL28741502 | 0.83 | MDM4 (0.52) | MDM2MAPTTDP1 | |
| SCHEMBL28741504 | 0.83 | MDM4 (0.52) | MDM2MAPTTDP1 | |
| SCHEMBL31097655 | 0.82 | HDAC8 (0.49) | PTPN1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |