Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346421 | 0.87 | KMT2A (0.45) | ALOX15ALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL8014852 | 0.81 | MMP3 (0.48) | ALOX15TP53ALDH1A1NPSR1MAPK1 | |
| SCHEMBL8003306 | 0.74 | TSHR (0.55) | SMN1; SMN2ALOX15TP53POLBALDH1A1 | |
| SCHEMBL7346276 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2ALOX15TP53TDP1POLB | |
| SCHEMBL8008082 | 0.72 | PTGES (0.47) | TP53ALDH1A1NPSR1LMNAPKM | |
| SCHEMBL16894124 | 0.71 | MMP1 (0.62) | SMN1; SMN2ALOX15TP53TDP1POLB | |
| SCHEMBL27540154 | 0.70 | MMP3 (0.48) | SMN1; SMN2ALOX15TP53POLBALDH1A1 | |
| SCHEMBL8016087 | 0.69 | TSHR (0.49) | SMN1; SMN2POLBALDH1A1LMNAMAPT | |
| Water SCHEMBL8018794 | 0.68 | TSHR (0.49) | SMN1; SMN2POLBALDH1A1LMNAMAPT | |
| SCHEMBL7344377 | 0.67 | SMN1; SMN2 (0.48) | SMN1; SMN2ALOX15TP53POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0895988-B1 | Arylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2002-05-22 | — | — | EP | disclosed |
| US-6107337-A | ANTIARTHRITIC AGENTS; ANTICARCINOGENIC AGENTS | PFIZER INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0895988-A1 | Arylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-02-10 | — | — | EP | disclosed |