Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 5/20 | 0.40 |
| ▸ | MMP9 | P14780 | 5/20 | 0.40 |
| ▸ | MMP1 | P03956 | 4/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | ADAMTS7 | Q9UKP4 | 2/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346428 | 0.88 | MMP1 (0.43) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL8014858 | 0.82 | MMP2 (0.45) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL8015533 | 0.75 | MMP1 (0.42) | SMN1; SMN2ALOX15MMP2MMP9MMP1 | |
| SCHEMBL8003307 | 0.75 | ALDH1A1 (0.51) | SMN1; SMN2MMP2MMP9MMP1MMP3 | |
| SCHEMBL7346271 | 0.73 | SMN1; SMN2 (0.52) | SMN1; SMN2ALOX15MAPTMMP1MMP3 | |
| SCHEMBL8008086 | 0.72 | PTGES (0.46) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7534393 | 0.72 | ADAMTS7 (0.47) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7534389 | 0.72 | ADAMTS7 (0.47) | MMP2MMP9MMP1MMP3MMP13 | |
| SCHEMBL7344377 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2ALOX15MMP2MMP9MMP1 | |
| SCHEMBL8012719 | 0.70 | BMP1 (0.49) | MMP2MMP9MMP1MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0895988-B1 | Arylsulfonylamino hydroxamic acid derivatives | PFIZER PROD INC (US) | 2002-05-22 | — | — | EP | disclosed |
| US-6107337-A | ANTIARTHRITIC AGENTS; ANTICARCINOGENIC AGENTS | PFIZER INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0895988-A1 | Arylsulfonylamino hydroxamic acid derivatives | Pfizer Products Inc. (US) | 1999-02-10 | — | — | EP | disclosed |