Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2800846 | 0.79 | LMNA (0.48) | DRD1LMNAKMT2AMEN1THRB | |
| SCHEMBL9712093 | 0.76 | TRIM24 (0.47) | DRD1LMNAKMT2AMEN1THRB | |
| SCHEMBL11497569 | 0.76 | NFKB1 (0.50) | DRD1LMNATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3196146 | 0.75 | KMT2A (0.60) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL18150545 | 0.73 | SRC (0.40) | DRD1LMNAALDH1A1TSHRERN1 | |
| SCHEMBL18753527 | 0.72 | ALDH1A1 (0.42) | DRD1LMNAKMT2AMEN1THRB | |
| SCHEMBL13893056 | 0.71 | LMNA (0.55) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL9732046 | 0.71 | LMNA (0.55) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL8973253 | 0.71 | LMNA (0.55) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL18627019 | 0.71 | LMNA (0.55) | LMNAKMT2AMEN1THRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4738965-A | NON TOXIC VASODILATOR | INSTITUT ORGANISCHSKOGO SINTEZA AKADEMII NAUK SSR (SU) | 1988-04-19 | — | — | US | disclosed |
| EP-0111455-A2 | Unsaturated lactones | CIBA-GEIGY AG (CH) | 1984-06-20 | — | — | EP | disclosed |
| US-4435574-A | HYPOTENSIVE AGENTS | KASTRON VALERIA V (SU) | 1984-03-06 | — | — | US | disclosed |