Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 14/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 14/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 8/20 | 0.50 |
| ▸ | KCNJ8 | Q15842 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347334 | 0.87 | P2RX7 (0.58) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL7352529 | 0.85 | ABCC9 (0.48) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL7347341 | 0.79 | ADRB2 (0.42) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL9456841 | 0.76 | ABCC9 (0.73) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL7349440 | 0.75 | ABCC9 (0.58) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL9151647 | 0.74 | NAMPT (0.51) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL7357467 | 0.74 | ABCC9 (0.57) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL7348943 | 0.73 | ABCC9 (0.54) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL7360174 | 0.72 | NAMPT (0.50) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 | |
| SCHEMBL11157791 | 0.71 | ABCC9 (0.70) | ABCC9KCNJ11ABCC8KCNJ8CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655057-B1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | UPJOHN CO (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5567722-A | DIURETICS | THE UPJOHN COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| WO-1994004500-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |