Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351795 | 0.93 | HTR7 (0.44) | HTR7HTR1ACARM1PRMT6CYP2D6 | |
| SCHEMBL6466592 | 0.93 | HTR7 (0.55) | HTR7HTR1AMCHR1SLC6A12TMEM97 | |
| SCHEMBL6458101 | 0.92 | HTR7 (0.54) | HTR7HTR1AMCHR1SLC6A12TMEM97 | |
| SCHEMBL6462598 | 0.92 | HTR7 (0.54) | HTR7HTR1AMCHR1SLC6A12TMEM97 | |
| SCHEMBL6457221 | 0.91 | HTR7 (0.55) | HTR7HTR1AMCHR1SLC6A12TMEM97 | |
| SCHEMBL7351045 | 0.89 | HTR7 (0.47) | HTR7HTR1ASSTR5 | |
| SCHEMBL6462987 | 0.86 | HTR7 (0.47) | HTR7HTR1ACARM1PRMT6CYP2D6 | |
| SCHEMBL6457124 | 0.86 | ADRA1D (0.50) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL6457611 | 0.86 | SLC6A5 (0.51) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7348639 | 0.85 | HTR7 (0.44) | HTR7HTR1ASSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | disclosed |
| EP-1026165-A1 | O-substituted Hydroxycoumaranone derivatives as antitumor and antimetastatic agents | Roche Diagnostics GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |