Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340024 | 0.80 | ALDH1A1 (0.39) | LMNAHPGDSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7338177 | 0.79 | TTR (0.43) | LMNAGAAMAPTKMT2AMEN1 | |
| SCHEMBL6783457 | 0.77 | ITGB3 (0.45) | LMNAHPGDSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL7835669 | 0.76 | ALDH1A1 (0.39) | LMNAHPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7339725 | 0.76 | ITGB3 (0.44) | LMNAHPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7344218 | 0.74 | HTT (0.46) | ALDH1A1GAAMAPTKMT2AMEN1 | |
| SCHEMBL6778093 | 0.74 | LMNA (0.43) | LMNAHPGDALDH1A1MAPTKMT2A | |
| SCHEMBL7349763 | 0.71 | ITGB3 (0.48) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL7348718 | 0.71 | KMT2A (0.39) | SMN1; SMN2ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL7347036 | 0.70 | HPGD (0.42) | LMNAHPGDSMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |