Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 2/20 | 0.54 |
| ▸ | STS | P08842 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | REN | P00797 | 2/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276597 | 0.82 | POLB (0.65) | YAP1MAPK1ALDH1A1 | |
| SCHEMBL7276592 | 0.82 | POLB (0.65) | YAP1MAPK1ALDH1A1 | |
| SCHEMBL7332179 | 0.81 | MMP2 (0.51) | ALDH1A1MAPT | |
| SCHEMBL7332174 | 0.81 | MMP2 (0.51) | ALDH1A1MAPT | |
| SCHEMBL30818350 | 0.80 | MMP13 (0.59) | P2RX7ALDH1A1MAPT | |
| SCHEMBL6165580 | 0.79 | MAPK1 (0.75) | YAP1STSMAPK1ALDH1A1 | |
| SCHEMBL6165579 | 0.79 | MAPK1 (0.75) | YAP1STSMAPK1ALDH1A1 | |
| SCHEMBL7336528 | 0.79 | TSHR (0.50) | YAP1STSP2RX7GPR119ALDH1A1 | |
| SCHEMBL8683934 | 0.79 | ALDH1A1 (0.58) | ALDH1A1MAPT | |
| SCHEMBL10059226 | 0.77 | STS (0.60) | YAP1STSP2RX7GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198426-A | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
| EP-0380805-A1 | Renin inhibitors containing C-terminal dihydroxy amides | WARNER-LAMBERT COMPANY (US) | 1990-08-08 | — | — | EP | disclosed |
| WO-1990007521-A1 | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |