Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 6/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361249 | 0.89 | HDAC3 (0.47) | SMN1; SMN2BACE1SYKMEN1KMT2A | |
| SCHEMBL30386744 | 0.84 | ITGA4 (0.41) | SMN1; SMN2BACE1SYKMEN1KMT2A | |
| SCHEMBL25913071 | 0.81 | SLC7A5 (0.42) | SMN1; SMN2MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL7944753 | 0.79 | BACE1 (0.46) | SMN1; SMN2BACE1SYKMEN1KMT2A | |
| SCHEMBL11893184 | 0.77 | PRSS1 (0.48) | SLC7A5 | |
| Hydrochloric Acid SCHEMBL15251850 | 0.76 | LOXL2 (0.49) | — | |
| SCHEMBL7385091 | 0.76 | LOXL2 (0.55) | SMN1; SMN2SLC7A5RAB9A | |
| SCHEMBL7498986 | 0.75 | PLAU (0.47) | SMN1; SMN2KMT2APPARGPPARAPLAU | |
| SCHEMBL25054127 | 0.74 | SYK (0.55) | SYKMEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL1680609 | 0.74 | BCHE (0.54) | SMN1; SMN2PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228854-B1 | 1-BENZAZEPINE DERIVATIVE ANTICOAGULANTS; STROKE PREVENTION | COR THERAPEUTICS, INC. | 2001-05-08 | — | — | US | disclosed |
| EP-0994894-A1 | SELECTIVE FACTOR Xa INHIBITORS | COR THERAPEUTICS, INC. (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999007731-A1 | SELECTIVE FACTOR Xa INHIBITORS | COR THERAPEUTICS, INC. (US) | 1999-02-18 | — | — | WO | disclosed |