Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343619 | 0.91 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL7347718 | 0.91 | KCNH2 (0.53) | KCNH2HTR1AMAPTDRD4 | |
| SCHEMBL7353705 | 0.87 | KCNH2 (0.52) | KCNH2HTR1A | |
| SCHEMBL7343246 | 0.84 | ADRA1A (0.55) | HTR1AALDH1A1 | |
| SCHEMBL4524281 | 0.82 | KCNH2 (1.00) | KCNH2HTR1AABCB1MAPTTSHR | |
| SCHEMBL7355250 | 0.79 | HTR1A (0.52) | HTR1AMAPT | |
| SCHEMBL13711973 | 0.78 | KCNH2 (0.87) | KCNH2ABCB1MAPTTSHRALDH1A1 | |
| SCHEMBL7347383 | 0.76 | SLC6A3 (0.43) | — | |
| SCHEMBL7344857 | 0.75 | KCNH2 (0.52) | KCNH2HTR1ADRD4 | |
| SCHEMBL7350903 | 0.75 | KCNH2 (0.76) | KCNH2HTR1AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | disclosed |