Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 10/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355250 | 0.91 | HTR1A (0.52) | ADRA1AADRA1DADRA1BDRD2DRD3 | |
| SCHEMBL7350906 | 0.84 | KCNH2 (0.67) | HTR1AALDH1A1 | |
| SCHEMBL7347718 | 0.83 | KCNH2 (0.53) | DRD2DRD3HTR1AHSD17B10 | |
| SCHEMBL7343619 | 0.79 | KCNH2 (0.54) | DRD2HTR7 | |
| SCHEMBL7353705 | 0.79 | KCNH2 (0.52) | ADRA1ADRD3HTR1A | |
| SCHEMBL27715320 | 0.78 | KCNH2 (0.72) | ADRA1ADRD2DRD3HTR7HTR1A | |
| SCHEMBL7347383 | 0.76 | SLC6A3 (0.43) | — | |
| SCHEMBL9368409 | 0.74 | DRD4 (0.59) | ADRA1AADRA1DADRA1BDRD2DRD3 | |
| SCHEMBL7351875 | 0.74 | ADRA1A (0.56) | ADRA1AADRA1DADRA1BDRD2DRD3 | |
| SCHEMBL7343240 | 0.74 | DRD2 (0.59) | ADRA1AADRA1DADRA1BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | claimed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | claimed |
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | disclosed |