Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.52 |
| ▸ | HTR7 | P34969 | 7/20 | 0.52 |
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343246 | 0.91 | ADRA1A (0.55) | HTR1AHTR7DRD2ADRA1AADRA1D | |
| SCHEMBL7343619 | 0.85 | KCNH2 (0.54) | HTR7DRD2 | |
| SCHEMBL7350906 | 0.79 | KCNH2 (0.67) | HTR1AMAPT | |
| SCHEMBL7347718 | 0.78 | KCNH2 (0.53) | HTR1ADRD2HTR2AHTR6DRD3 | |
| SCHEMBL7353705 | 0.77 | KCNH2 (0.52) | HTR1AADRA1ADRD3 | |
| SCHEMBL7347383 | 0.76 | SLC6A3 (0.43) | — | |
| SCHEMBL7355246 | 0.75 | HTR1A (0.60) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL10676614 | 0.72 | DRD2 (0.68) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL7351805 | 0.72 | HTR1A (0.52) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL10546259 | 0.70 | DRD2 (0.63) | HTR1AHTR7DRD2HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536279-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1993-04-14 | — | — | EP | claimed |
| WO-1992000282-A1 | SUBSTITUTED 1-(ALKOXYPHENYL)PIPERAZINES WITH CNS AND ANTIHYPERTENSIVE ACTIVITY | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | claimed |