Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.60 |
| ▸ | MMP1 | P03956 | 6/20 | 0.60 |
| ▸ | MMP9 | P14780 | 6/20 | 0.53 |
| ▸ | MMP2 | P08253 | 6/20 | 0.53 |
| ▸ | MMP8 | P22894 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 5/20 | 0.52 |
| ▸ | MMP7 | P09237 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | MMP16 | P51512 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934594 | 0.85 | MMP1 (0.73) | MMP13MMP1MMP9MMP2MMP8 | |
| SCHEMBL6929276 | 0.83 | MMP1 (0.70) | MMP13MMP1MMP9MMP2MMP8 | |
| SCHEMBL7207035 | 0.83 | MMP1 (0.54) | MMP13MMP1MMP9MMP2MMP8 | |
| SCHEMBL28548434 | 0.82 | NPC1 (0.54) | MMP13MMP1MMP9MMP2MMP8 | |
| SCHEMBL16540402 | 0.80 | MMP13 (0.55) | MMP13MMP1MMP9MMP2MMP8 | |
| SCHEMBL5157759 | 0.80 | MMP1 (0.51) | MMP13MMP1MMP9MMP2CA1 | |
| SCHEMBL28230363 | 0.79 | CA1 (0.54) | MMP13MMP1MMP9MMP2MMP8 | |
| SCHEMBL22206134 | 0.79 | CA1 (0.54) | MMP13MMP1MMP9MMP2MMP8 | |
| SCHEMBL7415077 | 0.79 | MMP9 (0.53) | MMP13MMP1MMP9MMP2MMP8 | |
| SCHEMBL4195254 | 0.79 | PKM (0.61) | MMP13MMP1MMP9MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970046-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | American Cyanamid Company (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998038163-A1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-09-03 | — | — | WO | disclosed |