Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.49 |
| ▸ | F2 | P00734 | 2/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356492 | 0.89 | F2 (0.52) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL7353174 | 0.83 | F2 (0.49) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL18843703 | 0.81 | GFER (0.53) | MAPTTSHRS1PR1NPC1TP53 | |
| SCHEMBL7353169 | 0.81 | ITGB3 (0.53) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL7358257 | 0.79 | ITGB3 (0.71) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL14013923 | 0.78 | HRH3 (0.57) | MAPTNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL7344477 | 0.75 | ITGB3 (0.72) | ITGB3ITGA2BF2PRSS1PRSS2 | |
| SCHEMBL6701211 | 0.75 | ALDH1A1 (0.53) | ITGB3ITGA2BMAPTHPGDTSHR | |
| SCHEMBL16607366 | 0.74 | MEN1 (0.49) | ALOX15MAPTHPGDTSHRKMT2A | |
| SCHEMBL14367434 | 0.73 | ITGB3 (0.62) | ITGB3ITGA2BF2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0637304-A1 | 1-PIPERAZINEACETIC DERIVATIVES AS FIBRINOGEN RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-02-08 | — | — | EP | claimed |
| WO-1993022303-A1 | 1-PIPERAZINEACETIC DERIVATIVES AS FIBRINOGEN RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1993-11-11 | — | — | WO | claimed |