Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.56 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15285573 | 0.91 | TSHR (0.54) | ACHETDP1ALDH1A1MAPTTSHR | |
| Sulfuric Acid SCHEMBL6839879 | 0.86 | ACHE (0.68) | ACHETEAD4TDP1ALDH1A1POLB | |
| Sulfamate SCHEMBL28135386 | 0.84 | ACHE (0.65) | ACHETEAD4TDP1ALDH1A1POLB | |
| SCHEMBL29225799 | 0.84 | ACHE (0.65) | ACHETEAD4TDP1ALDH1A1POLB | |
| 4-Aminophenol SCHEMBL7141388 | 0.83 | ALDH1A1 (0.56) | TDP1ALDH1A1MAPTTSHRNT5E | |
| Sulfuric Acid SCHEMBL27705627 | 0.82 | ACHE (0.62) | ACHETEAD4TDP1ALDH1A1POLB | |
| Aniline SCHEMBL19717871 | 0.80 | TSHR (0.50) | TDP1ALDH1A1TSHRNT5EMEN1 | |
| Aniline SCHEMBL3823035 | 0.80 | TSHR (0.50) | TDP1ALDH1A1TSHRNT5EMEN1 | |
| SCHEMBL11782818 | 0.78 | TSHR (0.78) | ACHETDP1ALDH1A1POLBMAPT | |
| SCHEMBL8421197 | 0.78 | TSHR (0.78) | ACHETDP1ALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226427-B1 | METHOD FOR SIMULTANEOUSLY INSPECTING THE QUALITY OF THE MILK SECRETED BY AN ANIMAL AND DIAGNOSING ITS KETOSIS STATE | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-07-17 | — | — | EP | claimed |
| EP-0226427-A2 | Method for simultaneously inspecting the quality of the milk secreted by an animal and diagnosing its ketosis state | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1987-06-24 | — | — | EP | claimed |
| CN-111073866-B | PQQ-sGDH mutant, polynucleotide and application thereof in glucose detection | 英科隆生物技术（杭州）有限公司 | 2024-03-19 | — | — | CN | disclosed |
| US-10752934-B2 | PQQ-sGDH mutant, polynucleotide and glucose detection biosensor | LEADWAY (HK) LIMITED (CN) | 2020-08-25 | — | — | US | disclosed |
| US-10725055-B1 | Compounds for carbonyl sulfide/carbon disulfide/hydrogen sulfide release and methods of making and using the same | UNIVERSITY OF OREGON (US) | 2020-07-28 | — | — | US | disclosed |
| EP-3246402-B1 | IMPROVED MUTANTS OF PYRROLOQUINOLINE QUINONE DEPENDENT SOLUBLE GLUCOSE DEHYDROGENASE | ROCHE DIABETES CARE GMBH (DE) | 2020-05-20 | — | — | EP | disclosed |
| CN-111073866-A | PQQ-sGDH mutant, polynucleotide and application thereof in glucose detection | 英科隆生物技术（杭州）有限公司 | 2020-04-28 | — | — | CN | disclosed |
| CN-105331591-B | PQQ-sGDH mutant, polynucleotide and glucose detection device | 英科隆生物技术（杭州）有限公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-105331590-B | Soluble pyrroloquinoline quinone dependent glucose dehydrogenase mutant with improved glucose specificity, polynucleotide and application thereof | 英科隆生物技术（杭州）有限公司 | 2020-02-28 | — | — | CN | disclosed |
| EP-3521421-A1 | GENETICALLY ENGINEERED PYRROLOQUINOLINE QUINONE DEPENDENT GLUCOSE DEHYDROGENASE COMPRISING AN AMINO ACID INSERTION | Roche Diabetes Care GmbH (DE) | 2019-08-07 | — | — | EP | disclosed |
| US-20190048052-A1 | ANTI-MICROBIAL PEPTIDES AND COATINGS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2019-02-14 | — | — | US | disclosed |
| WO-2002034919-A1 | VARIANTS OF SOLUBLE PYRROLOQUINOLINE QUINONE-DEPENDENT GLUCOSE DEHYDROGENASE | ROCHE DIAGNOSTICS GMBH (DE) | 2002-05-02 | — | — | WO | disclosed |
| EP-0439585-B1 | IMMOBILISATION OF LIGANDS BY RADIO-DERIVATIZED POLYMERS | MAG GEORG MAYRHOFER & CO OHG (AT) | 1997-10-29 | — | — | EP | disclosed |
| US-5545554-A | Lactobacillus bulgaricus having decreased acid production and/or improved aroma and flavor production | NESTEC S.A. (CH) | 1996-08-13 | — | — | US | disclosed |
| EP-0638642-A1 | Lactobacillus bulgaricus having decreased acid production and/or improved aroma and flavor production, and food composition comprising said lactobacillus bulgaricus | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1995-02-15 | — | — | EP | disclosed |
| US-5196478-A | Polystyrene, assays | EPIPHARM ALLERGIE-SERVICE GESELLSCHAFT M.B.H. (AT) | 1993-03-23 | — | — | US | disclosed |
| EP-0439585-A1 | IMMOBILISATION OF LIGANDS BY RADIO-DERIVATIZED POLYMERS. | EPIPHARM ALLERGIE SERVICE (AT) | 1991-08-07 | — | — | EP | disclosed |
| EP-0226427-B1 | METHOD FOR SIMULTANEOUSLY INSPECTING THE QUALITY OF THE MILK SECRETED BY AN ANIMAL AND DIAGNOSING ITS KETOSIS STATE | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991002768-A1 | IMMOBILISATION OF LIGANDS BY RADIO-DERIVATIZED POLYMERS | EPIPHARM ALLERGIE-SERVICE GESELLSCHAFT M.B.H. (AT) | 1991-03-07 | — | — | WO | disclosed |
| EP-0226427-A2 | Method for simultaneously inspecting the quality of the milk secreted by an animal and diagnosing its ketosis state | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1987-06-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10725055-B1 | Compounds for carbonyl sulfide/carbon disulfide/hydrogen sulfide release and methods of making and using the same | CBS, SQOR, TST | ACHE 807/4885TEAD4 4777/4885TDP1 3622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.