SCHEMBL7354566

SCHEMBL7354566

CS(=O)(=O)NCCC1CCNCC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.38
CYP3A4 P08684 1/20 0.38
GABRA1 P14867 1/20 0.38
TSHR P16473 1/20 0.38
GABRG2 P18507 1/20 0.38
NFKB1 P19838 1/20 0.38
GABRB3 P28472 1/20 0.38
GABRA5 P31644 1/20 0.38
GABRA3 P34903 1/20 0.38
GABRA2 P47869 1/20 0.38
GABRA6 Q16445 1/20 0.38
ITGB3 P05106 6/20 0.36
ITGA2B P08514 6/20 0.36
KDM1A O60341 1/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
ICAM1 P05362 1/20 0.35
GNAI3 P08754 1/20 0.35
GNAO1 P09471 1/20 0.35
GNAI1 P63096 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11173459 0.98 GNAO1 (0.38) LMNACYP3A4GABRA1TSHRGABRG2
SCHEMBL8396887 0.86 SIRT2 (0.38) LMNACYP3A4KDM1AICAM1SIRT2
SCHEMBL20771326 0.81 ENPP1 (0.38) LMNACYP3A4GABRA1TSHRGABRG2
SCHEMBL122137 0.80 ALOX15 (0.42) LMNACYP3A4GABRA1TSHRGABRG2
SCHEMBL8397033 0.80 SIGMAR1 (0.42) ICAM1SIRT2SIRT1SIRT3SIGMAR1
SCHEMBL8392312 0.80 SIGMAR1 (0.42) ICAM1SIRT2SIRT1SIRT3SIGMAR1
Hydrochloric Acid SCHEMBL20775139 0.79 ENPP1 (0.39) LMNACYP3A4GABRA1TSHRGABRG2
Hydrochloric Acid SCHEMBL26599945 0.78 GNAI3 (0.43) LMNACYP3A4GABRA1TSHRGABRG2
SCHEMBL15451908 0.76 SIRT2 (0.41) CYP3A4NFKB1ITGB3ITGA2BKDM1A
SCHEMBL23727202 0.75 APLNR (0.37) LMNACYP3A4GABRA1TSHRGABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015104356-A1 ARYL SULTAM DERIVATIVES AS RORc MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2015-07-16 WO disclosed
WO-2014009447-A1 ARYL SULTAM DERIVATIVES AS RORc MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2014-01-16 WO disclosed
EP-0700383-B1 NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS SYNTEX INC (US) 1998-09-23 EP disclosed
EP-0815103-A1 TRYPSIN AND THROMBIN INHIBITORS Novartis AG (CH) 1998-01-07 EP disclosed
WO-1996029327-A1 TRYPSIN AND THROMBIN INHIBITORS NOVARTIS AG (CH) 1996-09-26 WO disclosed
EP-0700383-A1 NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS SYNTEX (U.S.A.) INC. (US) 1996-03-13 EP disclosed
WO-1994027965-A1 NOVEL 1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS SYNTEX (U.S.A.) INC. (US) 1994-12-08 WO disclosed
US-4370328-A Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines PFIZER INC. (US) 1983-01-25 US disclosed
US-4188391-A 4-[4-(Substituted)piperidino]quinazoline cardiac stimulants PFIZER INC. (US) 1980-02-12 US disclosed