Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353162 | 0.80 | RECQL (0.50) | HPGDRECQLKMT2AGAAKDM4E | |
| SCHEMBL13621182 | 0.77 | HTT (0.67) | HPGDRECQLMEN1KMT2APOLB | |
| SCHEMBL20879994 | 0.76 | HPGD (1.00) | HPGDRECQLMEN1KMT2APOLB | |
| SCHEMBL7352350 | 0.69 | LTA4H (0.45) | POLBGAASMN1; SMN2HTTKDM4E | |
| SCHEMBL13621137 | 0.69 | ALDH1A1 (0.57) | HPGDRECQLPOLBSMN1; SMN2ALOX15 | |
| SCHEMBL6690507 | 0.69 | ALOX15 (0.59) | HPGDRECQLPOLBGAASMN1; SMN2 | |
| SCHEMBL10041818 | 0.69 | KDM4E (0.62) | KMT2APOLBSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL29078401 | 0.69 | ALDH1A1 (0.75) | RECQLPOLBSMN1; SMN2HTTKDM4E | |
| SCHEMBL1303744 | 0.68 | SMN1; SMN2 (0.69) | HPGDRECQLMEN1KMT2APOLB | |
| SCHEMBL18657232 | 0.68 | GAA (0.58) | GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027332-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999018074-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Britol-Myers Squibb Pharma Company (US) | 1999-04-15 | — | — | WO | disclosed |