Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | VNN1 | O95497 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354647 | 0.80 | HPGD (0.61) | RECQLTSHRGAAKMT2AKDM4E | |
| SCHEMBL13621183 | 0.78 | HTT (0.73) | MAPTTSHRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5773892 | 0.75 | MAPT (0.56) | RECQLMAPTTSHRCYP3A4CYP2C9 | |
| SCHEMBL5773896 | 0.73 | VNN1 (0.58) | VNN1MAPTCXCR4KMT2AALDH1A1 | |
| SCHEMBL5777274 | 0.73 | NAMPT (0.61) | VNN1TSHRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2868175 | 0.73 | SIGMAR1 (0.58) | CXCR4CYP3A4CYP2C9CYP1A2KMT2A | |
| SCHEMBL10041824 | 0.70 | CHRNB2 (0.62) | ALDH1A1KDM4E | |
| SCHEMBL18657232 | 0.70 | GAA (0.58) | GAAKDM4E | |
| SCHEMBL1274303 | 0.69 | RECQL (0.71) | RECQLMAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5771372 | 0.69 | ACHE (0.58) | KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027332-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999018074-A1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | Britol-Myers Squibb Pharma Company (US) | 1999-04-15 | — | — | WO | disclosed |