Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 2/20 | 0.44 |
| ▸ | NAAA | Q02083 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356063 | 0.84 | ALOX5 (0.49) | KCNH2MAPTALOX5 | |
| SCHEMBL7349646 | 0.80 | CSNK1E (0.44) | NPC1JAK2RAB9APAX8KCNH2 | |
| SCHEMBL7357535 | 0.80 | CSNK1E (0.44) | NPC1JAK2RAB9APAX8KCNH2 | |
| SCHEMBL28388648 | 0.76 | ASAH1 (0.51) | NAAAASAH1ALDH1A1ACER2 | |
| SCHEMBL28422103 | 0.74 | ICMT (0.46) | ICMTALBNAAANPC1JAK2 | |
| SCHEMBL28318791 | 0.72 | CES2 (0.51) | ICMTALBNAAANPC1JAK2 | |
| SCHEMBL6052898 | 0.71 | SRC (0.50) | MEN1KMT2AALDH1A1ALOX5 | |
| SCHEMBL3133535 | 0.71 | SRC (0.50) | MEN1KMT2AALDH1A1ALOX5 | |
| SCHEMBL21359023 | 0.71 | EPHX1 (0.53) | NAAANPC1RAB9AASAH1LMNA | |
| SCHEMBL7642789 | 0.71 | EPHX1 (0.53) | NAAANPC1RAB9AASAH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |