Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | MC5R | P33032 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349646 | 1.00 | CSNK1E (0.44) | CSNK1EKCNH2MC4RMC5RMC3R | |
| SCHEMBL7353864 | 0.82 | CSNK1E (0.48) | CSNK1ECNR2 | |
| SCHEMBL7355176 | 0.80 | ICMT (0.44) | KCNH2NPC1JAK2RAB9APAX8 | |
| SCHEMBL7357801 | 0.77 | MMP8 (0.45) | — | |
| SCHEMBL7348722 | 0.75 | MMP8 (0.40) | EPHX1 | |
| SCHEMBL8917376 | 0.74 | MC4R (0.60) | CSNK1EKCNH2MC4RMC5RMC3R | |
| SCHEMBL7357356 | 0.74 | ALOX5 (0.54) | KCNH2 | |
| SCHEMBL7361196 | 0.74 | ALOX5 (0.50) | — | |
| SCHEMBL7356874 | 0.73 | UGCG (0.40) | CSNK1E | |
| SCHEMBL2109313 | 0.73 | EPHX1 (0.68) | EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |