Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355301 | 1.00 | REN (0.44) | RENACEENPEP | |
| SCHEMBL10431112 | 0.92 | REN (0.48) | RENACE | |
| SCHEMBL10447998 | 0.84 | REN (0.42) | REN | |
| SCHEMBL10447999 | 0.84 | REN (0.42) | REN | |
| SCHEMBL16359592 | 0.76 | ACE (0.39) | ACE | |
| SCHEMBL8252710 | 0.76 | REN (0.38) | RENACE | |
| SCHEMBL11010625 | 0.76 | REN (0.66) | REN | |
| SCHEMBL11013919 | 0.76 | REN (0.66) | REN | |
| SCHEMBL30684916 | 0.75 | LNPEP (0.42) | ACEENPEP | |
| SCHEMBL11009837 | 0.75 | ACE (0.34) | RENACEENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268374-A | Containing both amide and hydroxy groups | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0437508-A4 | NON-PEPTIDE RENIN INHIBITORS | — | 1991-11-06 | — | — | EP | disclosed |
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |