Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | THPO | P40225 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735249 | 0.85 | PRMT5 (0.34) | ADORA3ADORA1PRMT5WDR77 | |
| SCHEMBL11040441 | 0.85 | ADORA1 (0.40) | ADORA3ADORA2AADORA1ADORA2BLMNA | |
| SCHEMBL28249867 | 0.84 | ADORA3 (0.49) | ADORA3ADORA2AADORA1ADORA2BSMN1; SMN2 | |
| SCHEMBL7061902 | 0.82 | ADORA2A (0.43) | ADORA3ADORA2AADORA1ADORA2BSMN1; SMN2 | |
| SCHEMBL10481812 | 0.82 | ADORA1 (0.37) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL735342 | 0.80 | RNMT (0.31) | ADORA3ADORA1PRMT5WDR77 | |
| SCHEMBL9773301 | 0.79 | ADORA2A (0.36) | ADORA3ADORA2AADORA1ADORA2BTSHR | |
| SCHEMBL9354230 | 0.75 | MEN1 (0.38) | ADORA3ADORA2AADORA1ADORA2BNFKB1 | |
| SCHEMBL10430365 | 0.73 | ADORA2A (0.42) | ADORA3ADORA2AADORA1ADORA2BSMN1; SMN2 | |
| SCHEMBL6869101 | 0.73 | ADORA3 (0.42) | ADORA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138330-B2 | Solid phase synthesis via deblocking immobilized nucleoside, then coupling acyl protected nucleoside phosphoramidite | SIGMA-ALDRICH CO. LLC (US) | 2012-03-20 | — | — | US | disclosed |