Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | HTR1D | P28221 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060530 | 1.00 | HTR2A (0.57) | HTR2ACYP3A4HTR2CMPOCYP1A2 | |
| SCHEMBL8524609 | 0.86 | MEN1 (0.70) | HTR2ACYP3A4HTR2CMPOCYP1A2 | |
| SCHEMBL1993893 | 0.85 | MEN1 (0.74) | HTR2ACYP3A4HTR2CMPOCYP1A2 | |
| SCHEMBL4985934 | 0.84 | HTR2A (0.77) | HTR2ACYP3A4HTR2CMPOCYP1A2 | |
| SCHEMBL6168855 | 0.83 | MEN1 (0.56) | HTR2ACYP3A4HTR2CMPOCYP1A2 | |
| SCHEMBL26699137 | 0.81 | GPR84 (0.52) | HTR6MEN1KMT2AGPR84KDM4E | |
| SCHEMBL31744670 | 0.80 | HTR2A (0.57) | HTR2ACYP3A4HTR2CMPOCYP1A2 | |
| SCHEMBL7263795 | 0.80 | HTR2A (0.57) | HTR2ACYP3A4HTR2CMPOCYP1A2 | |
| SCHEMBL10969880 | 0.80 | GFER (0.65) | HTR2ACYP3A4HTR2CMPOCYP1A2 | |
| SCHEMBL18826588 | 0.80 | KMT2A (0.60) | HTR2ACYP3A4HTR2CMPOCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102046597-B | (hetero) arylcyclohexane derivatives | GRUENENTHAL GMBH | 2013-09-11 | — | — | CN | claimed |
| CN-102046597-A | (hetero) arylcyclohexane derivatives | GRUENENTHAL GMBH | 2011-05-04 | — | — | CN | claimed |
| EP-0065907-B1 | ((TETRA AND HEXAHYDRO-PYRIDYL-4)-2-ETHYL)-3 INDOLES, AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | PHARMUKA LABORATOIRES (FR) | 1984-12-05 | — | — | EP | claimed |
| EP-4662319-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | Integrate Bioscience LLC (US) | 2025-12-17 | — | — | EP | disclosed |
| WO-2024168301-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | FUNCTION ONCOLOGY, INC. (US) | 2024-08-15 | — | — | WO | disclosed |
| EP-2280941-B1 | (HETERO-)ARYL CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2015-05-06 | — | — | EP | disclosed |
| CN-101516844-B | 4-heteroaryl substituted 1-aminocyclohexane-1-and cyclohexene-1-derivatives having activity on opioid receptor systems | GRUENENTHAL GMBH | 2013-12-11 | — | — | CN | disclosed |
| CN-102046597-B | (hetero) arylcyclohexane derivatives | GRUENENTHAL GMBH | 2013-09-11 | — | — | CN | disclosed |
| WO-2013086002-A1 | COMPOSITIONS, PROCESS OF PREPARATION OF SAID COMPOSITIONS AND METHOD OF TREATING CANCER | CELLWORKS RESEARCH INDIA PRIVATE LIMITED (IN) | 2013-06-13 | — | — | WO | disclosed |
| WO-2013086002-A1 | COMPOSITIONS, PROCESS OF PREPARATION OF SAID COMPOSITIONS AND METHOD OF TREATING CANCER | CELLWORKS RESEARCH INDIA PRIVATE LIMITED (IN) | 2013-06-13 | — | — | WO | disclosed |
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | disclosed |
| US-7977370-B2 | (Hetero)aryl cyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2011-07-12 | — | — | US | disclosed |
| CN-102046597-A | (hetero) arylcyclohexane derivatives | GRUENENTHAL GMBH | 2011-05-04 | — | — | CN | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| US-20090247573-A1 | (HETERO)ARYL CYCLOHEXANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
| CN-101516844-A | 4-heteroaryl substituted 1-aminocyclohexane-1-and cyclohexene-1-derivatives having activity on opioid receptor systems | GRUENENTHAL GMBH (DE) | 2009-08-26 | — | — | CN | disclosed |
| EP-2044016-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009415-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1- AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | disclosed |
| US-20050124620-A1 | Indole derivatives having an acidic moiety that inhibit or modulate activity of p38 map kinase mediating a disease state; e.g., 3-(2-(4-pyridyl)ethyl)-5-(3-trifluoromethoxybenzamido)indole; enzyme inhibitors; antiarthritic, -inflammatory, and -carcinogenic agents; respiratory disorders; AIDS; Alzheimer's | FREDERICKSON MARTYN (GB) | 2005-06-09 | — | — | US | disclosed |
| US-4478841-A | HEADACHES, ANTICOAGULANTS, THYMOANALEPTIC | PHARMUKA LABORATOIRES (FR) | 1984-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124620-A1 | Indole derivatives having an acidic moiety that inhibit or modulate activity of p38 map kinase mediating a disease state; e.g., 3-(2-(4-pyridyl)ethyl)-5-(3-trifluoromethoxybenzamido)indole; enzyme inhibitors; antiarthritic, -inflammatory, and -carcinogenic agents; respiratory disorders; AIDS; Alzheimer's | MAPK1, IDO1, INMT | HTR2A 1350/4885CYP3A4 1382/4885HTR2C 1176/4885 |
| US-20090247573-A1 | (HETERO)ARYL CYCLOHEXANE DERIVATIVES | OPRL1, OPRM1, OPRD1 | HTR2A 83/4885CYP3A4 385/4885HTR2C 28/4885 |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | HTR2A 238/4885CYP3A4 8/4885HTR2C 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.