SCHEMBL7356282

SCHEMBL7356282

CCCOc1ccccc1S(=O)(=O)Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
TRPV4 Q9HBA0 2/20 0.42
MEN1 O00255 5/20 0.42
KMT2A Q03164 5/20 0.42
HTR2C P28335 1/20 0.41
HTR2B P41595 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
MAPT P10636 2/20 0.40
CYP2A6 P11509 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MCOLN3 Q8TDD5 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL995712 0.91 CYP1A2 (0.51) TRPV4MEN1KMT2AHTR2BCYP1A2
SCHEMBL3371631 0.90 CYP3A4 (0.49) NPC1RAB9ATRPV4MEN1KMT2A
SCHEMBL10945251 0.88 LMNA (0.51) MEN1KMT2AHTR2BCYP1A2CYP2C9
SCHEMBL10652106 0.88 LMNA (0.51) MEN1KMT2AHTR2BCYP1A2CYP2C9
SCHEMBL7363474 0.88 LMNA (0.51) MEN1KMT2AHTR2BCYP1A2CYP2C9
SCHEMBL31511099 0.85 TRPV4 (0.55) TRPV4MAPTNPSR1L3MBTL1CA12
SCHEMBL8726763 0.85 TRPV4 (0.55) TRPV4MAPTNPSR1L3MBTL1CA12
SCHEMBL498544 0.84 MEN1 (0.43) NPC1RAB9AMEN1KMT2AHTR2C
SCHEMBL17861662 0.84 CASR (0.43) NPC1RAB9AMEN1KMT2AHTR2C
SCHEMBL1649916 0.82 CA1 (0.50) NPC1RAB9AMEN1KMT2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3630769-A1 NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF Topadur Pharma AG (CH) 2020-04-08 EP disclosed
WO-2018215433-A1 NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF TOPADUR PHARMA AG (CH) 2018-11-29 WO disclosed
EP-0778839-B1 NOVEL PHOSPHANE OXIDES, METHOD OF PREPARING THEM AND DRUGS CONTAINING THESE COMPOUNDS BOEHRINGER MANNHEIM GMBH (DE) 1998-12-23 EP disclosed
US-5824679-A Phosphanoxides--preparation and use BOEHRINGER MANNHEIM GMBH (DE) 1998-10-20 US disclosed
EP-0778839-A1 NOVEL PHOSPHANE OXIDES, METHOD OF PREPARING THEM AND DRUGS CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1997-06-18 EP disclosed
WO-1996006849-A1 NOVEL PHOSPHANE OXIDES, METHOD OF PREPARING THEM AND DRUGS CONTAINING THESE COMPOUNDS BOEHRINGER MANNHEIM GMBH (DE) 1996-03-07 WO disclosed