SCHEMBL7356318

SCHEMBL7356318

CC(C)(C)OC(=O)C(CN1CCNC(=O)C1)Nc1ccncc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.39
ALDH1A1 P00352 1/20 0.36
POLB P06746 1/20 0.36
F2 P00734 1/20 0.35
MAPK1 P28482 1/20 0.33
CYP17A1 P05093 1/20 0.33
SCN9A Q15858 1/20 0.33
KEAP1 Q14145 1/20 0.33
NFE2L2 Q16236 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
PRMT5 O14744 1/20 0.32
WDR77 Q9BQA1 1/20 0.32
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
BUB1 O43683 1/20 0.32
TRPV4 Q9HBA0 1/20 0.32
TSHR P16473 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7366801 0.80 SMN1; SMN2 (0.36) SMN1; SMN2ALDH1A1POLBF2PDCD1
SCHEMBL7364312 0.78 ALDH1A1 (0.35) SMN1; SMN2ALDH1A1POLBF2MAPK1
SCHEMBL5504851 0.76 TSHR (0.39) SMN1; SMN2ALDH1A1POLBMAPK1TDP1
SCHEMBL7361998 0.75 TSHR (0.38) SMN1; SMN2ALDH1A1POLBMAPK1SCN9A
SCHEMBL1651503 0.72 SMN1; SMN2 (0.39) SMN1; SMN2ALDH1A1POLBF2MEN1
SCHEMBL8499683 0.68 L3MBTL1 (0.39) SMN1; SMN2ALDH1A1MAPK1TRPV4THRB
SCHEMBL8501813 0.68 SMN1; SMN2 (0.37) SMN1; SMN2ALDH1A1POLBMAPK1PDCD1
SCHEMBL28507628 0.68 SMN1; SMN2 (0.45) SMN1; SMN2ALDH1A1POLBMAPK1TDP1
SCHEMBL13238482 0.66 DRD2 (0.47) ALDH1A1TDP1MEN1KMT2ATHRB
SCHEMBL5549908 0.64 SMN1; SMN2 (0.39) SMN1; SMN2ALDH1A1POLBTDP1PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051176-A4 SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS AVENTIS PHARM PROD INC (US) 2002-06-12 EP disclosed
EP-1051176-A1 SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS Aventis Pharmaceuticals Products Inc. (US) 2000-11-15 EP disclosed
WO-2000032590-A1 SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 2000-06-08 WO disclosed
WO-1999037304-A1 SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-07-29 WO disclosed