SCHEMBL7357302

SCHEMBL7357302

O=C(O)c1cccc2ccc3c(c12)CCCO3

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 3/20 0.55
MTNR1B P49286 2/20 0.55
HSD17B10 Q99714 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.38
CTNNB1 P35222 3/20 0.38
WNT3A P56704 3/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
ALDH1A1 P00352 2/20 0.37
KDM4E B2RXH2 1/20 0.37
TSHR P16473 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
GFER P55789 1/20 0.37
NR4A1 P22736 1/20 0.37
NR4A2 P43354 1/20 0.37
NR4A3 Q92570 1/20 0.37
HTR1A P08908 2/20 0.36
HTR1D P28221 2/20 0.36
HTR2A P28223 2/20 0.36
HTR2C P28335 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL984633 0.82 SMN1; SMN2 (0.44) MTNR1AMTNR1BHSD17B10SMN1; SMN2CTNNB1
SCHEMBL8299291 0.77 GFER (0.44) SMN1; SMN2MEN1KMT2AALDH1A1GFER
SCHEMBL7476564 0.73 SMN1; SMN2 (0.41) MTNR1AMTNR1BHSD17B10SMN1; SMN2CTNNB1
SCHEMBL7007385 0.72 MTNR1A (0.47) MTNR1AMTNR1BALDH1A1KDM4EHTR1A
Cyclohexane SCHEMBL28012770 0.72 HSD17B10 (0.69) HSD17B10SMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL2834703 0.72 HSD17B10 (0.75) HSD17B10SMN1; SMN2MEN1KMT2AALDH1A1
SCHEMBL24116602 0.72 HSD17B10 (0.50) HSD17B10SMN1; SMN2CTNNB1MEN1KMT2A
SCHEMBL496918 0.72 SLC9A1 (0.43) MTNR1AMTNR1BSMN1; SMN2ALDH1A1KDM4E
Ammonia Solution, Strong SCHEMBL27534728 0.71 MTNR1A (0.46) MTNR1AMTNR1BALDH1A1KDM4EHTR1A
SCHEMBL1387212 0.71 MTNR1A (1.00) MTNR1AMTNR1BHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0664794-A1 N-ALKYLPIPERIDINYL-4-METHYL CARBOXYLIC ESTERS/AMIDES OF CONDENSED RING SYSTEMS AS 5-HT4 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-08-02 EP disclosed
WO-1994008965-A1 N-ALKYLPIPERIDINYL-4-METHYL CARBOXYLIC ESTERS/AMIDES OF CONDENSED RING SYSTEMS AS 5-HT4 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-04-28 WO disclosed