Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7150868 | 0.78 | PDE4B (0.39) | PDE4BTRPC6CNR2 | |
| SCHEMBL7148906 | 0.77 | PDE4B (0.42) | PDE4BTRPC6 | |
| SCHEMBL6156937 | 0.77 | PDE4B (0.48) | PDE4B | |
| SCHEMBL3633786 | 0.74 | TRPC6 (0.54) | PDE4BTRPC6CNR2 | |
| SCHEMBL88281 | 0.68 | TRPC6 (0.49) | PDE4BTRPC6CNR2 | |
| SCHEMBL18708221 | 0.68 | TRPC6 (0.49) | PDE4BTRPC6CNR2 | |
| SCHEMBL71158 | 0.67 | TRPC6 (0.48) | PDE4BTRPC6CNR2 | |
| SCHEMBL7379374 | 0.67 | PDE4B (0.50) | PDE4B | |
| SCHEMBL7619551 | 0.66 | PDE4B (0.51) | PDE4B | |
| SCHEMBL15757242 | 0.65 | PDE4B (0.41) | PDE4BTRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068194-A1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999050262-A1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-10-07 | — | — | WO | disclosed |