Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7150868 | 0.77 | PDE4B (0.39) | PDE4BTRPC6PDE4DPDE4A | |
| SCHEMBL7357472 | 0.77 | PDE4B (0.41) | PDE4BTRPC6 | |
| SCHEMBL7617504 | 0.77 | PDE4B (0.58) | PDE4BPDE4DPDE4A | |
| SCHEMBL15757242 | 0.73 | PDE4B (0.41) | PDE4BTRPC6PDE4DPDE4A | |
| SCHEMBL18708222 | 0.73 | PDE4D (0.44) | PDE4BTRPC6PDE4DPDE4A | |
| SCHEMBL3633786 | 0.72 | TRPC6 (0.54) | PDE4BTRPC6PDE4DPDE4A | |
| SCHEMBL18715212 | 0.71 | CNR2 (0.41) | PDE4BDHFRTRPC6PDE4DPDE4A | |
| SCHEMBL18708221 | 0.70 | TRPC6 (0.49) | PDE4BTRPC6PDE4DPDE4A | |
| SCHEMBL88281 | 0.70 | TRPC6 (0.49) | PDE4BTRPC6PDE4DPDE4A | |
| SCHEMBL30352570 | 0.70 | PDE4B (0.63) | PDE4BPDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656959-B1 | PDE IV inhibiting pyridine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-02 | — | — | US | disclosed |
| EP-1068194-B1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-11-05 | — | — | EP | disclosed |
| EP-1068194-A1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999052879-A1 | ACYLRESORCINOL DERIVATIVES AS SELECTIVE VITRONECTIN RECEPTOR INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |
| WO-1999050262-A1 | PDE IV INHIBITING PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-10-07 | — | — | WO | disclosed |