Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733324 | 0.72 | SLC18A3 (0.38) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19746393 | 0.69 | NPC1 (0.46) | RAB9ANPC1LMNAAKR1C3AKR1C1 | |
| SCHEMBL10778292 | 0.68 | — | — | |
| SCHEMBL13264346 | 0.68 | KDM1A (0.38) | LMNAALDH1A1 | |
| SCHEMBL12490831 | 0.68 | OAT (0.48) | KMT2ALMNATSHRPOLB | |
| SCHEMBL20600221 | 0.68 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2AKR1C3AKR1C1 | |
| Biphenyl SCHEMBL7611759 | 0.67 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| Biphenyl SCHEMBL11881576 | 0.67 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11560802 | 0.65 | MTNR1A (0.37) | SMN1; SMN2MEN1KMT2AAKR1C3AKR1C1 | |
| SCHEMBL7873912 | 0.65 | F2 (0.42) | RAB9ANPC1SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655057-B1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | UPJOHN CO (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5567722-A | DIURETICS | THE UPJOHN COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0655057-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS. | UPJOHN CO (US) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994004500-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |