Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 5/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356361 | 0.83 | PANK3 (0.39) | PANK3DRD2CNR2OGADRD4 | |
| SCHEMBL4856131 | 0.80 | PANK3 (0.43) | PANK3DRD2CNR2OGADRD4 | |
| SCHEMBL4814569 | 0.73 | MMP7 (0.46) | PANK3DRD2CNR2OGADRD4 | |
| SCHEMBL4754484 | 0.70 | GPR119 (0.54) | PANK3DRD2CNR2DRD4GPR119 | |
| SCHEMBL7131238 | 0.68 | DRD2 (0.41) | PANK3DRD2CNR2DRD4GPR119 | |
| SCHEMBL2155271 | 0.68 | GPR119 (0.59) | PANK3CNR2GPR119L3MBTL1ALDH1A1 | |
| SCHEMBL7364401 | 0.67 | OGA (0.36) | OGAKMT2AHTR1AHTR7 | |
| SCHEMBL4958636 | 0.67 | GPR119 (0.46) | PANK3DRD2CNR2DRD4GPR119 | |
| SCHEMBL7150571 | 0.66 | PANK3 (0.43) | PANK3DRD2DRD4GPR119ALDH1A1 | |
| SCHEMBL7155176 | 0.65 | PANK3 (0.44) | PANK3DRD2DRD4GPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109787-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | AstraZeneca AB (SE) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012478-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |