SCHEMBL7359283

SCHEMBL7359283

CCOC(=O)[C@H]1N[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCC(C)C

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CAPN9 O14815 1/20 0.49
CAPN1 P07384 3/20 0.48
CTSL P07711 2/20 0.48
LMNA P02545 1/20 0.48
CTSB P07858 1/20 0.48
CTSG P08311 1/20 0.48
NMBR P28336 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
LAP3 P28838 3/20 0.46
ANPEP P15144 1/20 0.46
RNPEP Q9H4A4 1/20 0.46
DNPEP Q9ULA0 1/20 0.46
PLG P00747 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7363926 0.90 L3MBTL1 (0.47) NMBRL3MBTL1
SCHEMBL7361188 0.90 BACE1 (0.45) CAPN1CTSLCTSBL3MBTL1
SCHEMBL7354813 0.89 CTNNB1 (0.45) CAPN9CAPN1CTSLLMNACTSB
SCHEMBL7362797 0.88 SRC (0.47) L3MBTL1PLG
SCHEMBL7359406 0.88 MMP1 (0.49) L3MBTL1ANPEP
SCHEMBL7362904 0.87 LAP3 (0.51) CAPN9CAPN1CTSLCTSBNMBR
SCHEMBL7364449 0.87 CHRNB2 (0.47) L3MBTL1PLG
SCHEMBL7363069 0.87 PLG (0.52) L3MBTL1PLG
SCHEMBL7358752 0.87 L3MBTL1 (0.56) CTSLNMBRL3MBTL1LAP3ANPEP
SCHEMBL7363532 0.87 TSHR (0.46) LMNAL3MBTL1PLG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0753003-B1 AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-06-16 EP claimed
US-5668128-A INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-09-16 US claimed
EP-0753003-B1 AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-06-16 EP disclosed
US-5668128-A INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-09-16 US disclosed
EP-0753003-A1 AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-01-15 EP disclosed
WO-1995028416-A1 AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-10-26 WO disclosed