Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 10/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.52 |
| ▸ | PRSS2 | P07478 | 10/20 | 0.52 |
| ▸ | PRSS3 | P35030 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | PTPRA | P18433 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364449 | 0.92 | CHRNB2 (0.47) | PLGPRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL7362797 | 0.91 | SRC (0.47) | PLGPRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL8894917 | 0.89 | TSHR (0.49) | PLGPRSS1PRSS2PRSS3CHRNB2 | |
| SCHEMBL7359575 | 0.89 | TSHR (0.49) | PLGPRSS1PRSS2PRSS3CHRNB2 | |
| SCHEMBL8894925 | 0.89 | TSHR (0.49) | PLGPRSS1PRSS2PRSS3CHRNB2 | |
| SCHEMBL7363926 | 0.89 | L3MBTL1 (0.47) | KMT2AL3MBTL1 | |
| SCHEMBL8875868 | 0.88 | PLG (0.53) | PLGPRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL7363532 | 0.88 | TSHR (0.46) | PLGPRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL7359283 | 0.87 | CAPN9 (0.49) | PLGL3MBTL1 | |
| SCHEMBL7359406 | 0.87 | MMP1 (0.49) | KLKB1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753003-B1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-16 | — | — | EP | disclosed |
| US-5668128-A | INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| EP-0753003-A1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995028416-A1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-26 | — | — | WO | disclosed |